Iran is about to lose all these heads and deciders.....
It's possible that they could simply collapse, sure.
Nobody thought that the 50-year old Assad regime could fall in just a matter of two weeks.
Nobody anticipated how quickly Hezbollah would crumble without the charismatic leadership of Nasrallah.
It's possible that the Islamic Republic is also just one big rotten facade that will come crashing down with a further couple kicks.
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I don't see its collapse as likely, however, unless Israel and Washington can convince Russia and China that this is in its interests. I can't speak for China, but I can explain how Israel could convince Russia:
1) Russia has incredibly close ties with Israel, through our diaspora. Up to 15% of Israel's population, are people from the former Soviet Union. Becoming an enemy of our own former compatriots, and by proxy the rest of international Jewry - is maybe not in Russia's interest.
2) Russia has increasingly close ties with Saudi Arabia (where we steer OPEC+ together), and the UAE (where many rich Russians live, and which is conduit for a large part of the sanctions busting trade). These two states are incredibly nervous about living next to Iran. They could reward us handsomely for sitting out this fight.
3) Under no circumstances is Russia interested in Iran having a nuke. In the past Israel had convinced us to halt jet fighter exports to Iran, and also managed to restrict the S-400 anti-air shipments to just a single battery. If Israel manages to convince Russia that a nuclear Iran is a virtual inevitability, that could convince Russia to stay out.
4) Last year, Russia became Iran's largest foreign investor. Israel, or whoever they have convinced to come and run Iran (the Shah, some liberals, whomever), has to make representations that all Russian property rights will be respected - including in Iran's key oil and gas industry.
5) All other agreements must be respected as well. Including the trade liberalization agreements, and the agreement to build the civilian nuclear power plant at Bushehr.
6) Whatever critical imports we require from Iran in support of the military operation in Ukraine, must continue to flow.